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Bioactive natural compounds against human coronaviruses: a review and perspective.
Xian, Yanfang; Zhang, Juan; Bian, Zhaoxiang; Zhou, Hua; Zhang, Zhenbiao; Lin, Zhixiu; Xu, Hongxi.
  • Xian Y; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • Zhang J; Brain Research Centre, School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • Bian Z; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • Zhou H; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
  • Zhang Z; Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Lin Z; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
  • Xu H; School of Chinese Medicine, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong SAR, China.
Acta Pharm Sin B ; 10(7): 1163-1174, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-574770
ABSTRACT
Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the very recent coronavirus disease 2019 (COVID-19) outbreak. Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs. Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. In the past decades, many natural compounds have been reported to possess multiple biological activities, including antiviral properties. In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Acta Pharm Sin B Year: 2020 Document Type: Article Affiliation country: J.apsb.2020.06.002

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Acta Pharm Sin B Year: 2020 Document Type: Article Affiliation country: J.apsb.2020.06.002