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COVID-19 and androgen-targeted therapy for prostate cancer patients.
Bhowmick, Neil A; Oft, Jillian; Dorff, Tanya; Pal, Sumanta; Agarwal, Neeraj; Figlin, Robert A; Posadas, Edwin M; Freedland, Stephen J; Gong, Jun.
  • Bhowmick NA; Department of Medicine, Cedars-Sinai Cancer, Los Angeles, California, USA.
  • Oft J; Department of Research, Greater Los Angeles Veterans Administration, Los Angeles, California, USA.
  • Dorff T; Department of Infectious Diseases, Cedars-Sinai Medical Center, Los Angeles, California.
  • Pal S; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California.
  • Agarwal N; Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California.
  • Figlin RA; Department of Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, Utah.
  • Posadas EM; Department of Medicine, Cedars-Sinai Cancer, Los Angeles, California, USA.
  • Freedland SJ; Department of Medicine, Cedars-Sinai Cancer, Los Angeles, California, USA.
  • Gong J; Department of Surgery, Cedars-Sinai Cancer, Los Angeles, California.
Endocr Relat Cancer ; 27(9): R281-R292, 2020 09.
Article in English | MEDLINE | ID: covidwho-577793
Semantic information from SemMedBD (by NLM)
1. Androgen Therapy TREATS Malignant neoplasm of prostate
Subject
Androgen Therapy
Predicate
TREATS
Object
Malignant neoplasm of prostate
2. Malignant neoplasm of prostate PROCESS_OF Patients
Subject
Malignant neoplasm of prostate
Predicate
PROCESS_OF
Object
Patients
3. Androgen Therapy TREATS Patients
Subject
Androgen Therapy
Predicate
TREATS
Object
Patients
4. angiotensin converting enzyme 2 AUGMENTS Virus Internalization
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Virus Internalization
5. Human tissue LOCATION_OF angiotensin converting enzyme 2
Subject
Human tissue
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
6. Human tissue LOCATION_OF TMPRSS2 gene|TMPRSS2
Subject
Human tissue
Predicate
LOCATION_OF
Object
TMPRSS2 gene|TMPRSS2
7. TMPRSS2 gene|TMPRSS2 AFFECTS Malignant neoplasm of prostate
Subject
TMPRSS2 gene|TMPRSS2
Predicate
AFFECTS
Object
Malignant neoplasm of prostate
8. Antiandrogen therapy METHOD_OF Androgen Suppression
Subject
Antiandrogen therapy
Predicate
METHOD_OF
Object
Androgen Suppression
9. Androgen Suppression TREATS Malignant neoplasm of prostate
Subject
Androgen Suppression
Predicate
TREATS
Object
Malignant neoplasm of prostate
10. Androgens INTERACTS_WITH angiotensin converting enzyme 2
Subject
Androgens
Predicate
INTERACTS_WITH
Object
angiotensin converting enzyme 2
11. Androgens INTERACTS_WITH TMPRSS2 gene|TMPRSS2
Subject
Androgens
Predicate
INTERACTS_WITH
Object
TMPRSS2 gene|TMPRSS2
12. Androgens INHIBITS TMPRSS2 gene|TMPRSS2
Subject
Androgens
Predicate
INHIBITS
Object
TMPRSS2 gene|TMPRSS2
13. Androgens TREATS 2019 novel coronavirus
Subject
Androgens
Predicate
TREATS
Object
2019 novel coronavirus
14. Androgens TREATS COVID-19
Subject
Androgens
Predicate
TREATS
Object
COVID-19
15. Androgens TREATS Malignant neoplasm of prostate
Subject
Androgens
Predicate
TREATS
Object
Malignant neoplasm of prostate
16. Androgen Therapy TREATS Malignant neoplasm of prostate
Subject
Androgen Therapy
Predicate
TREATS
Object
Malignant neoplasm of prostate
17. Malignant neoplasm of prostate PROCESS_OF Patients
Subject
Malignant neoplasm of prostate
Predicate
PROCESS_OF
Object
Patients
18. Androgen Therapy TREATS Patients
Subject
Androgen Therapy
Predicate
TREATS
Object
Patients
19. angiotensin converting enzyme 2 AUGMENTS Virus Internalization
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Virus Internalization
20. Human tissue LOCATION_OF angiotensin converting enzyme 2
Subject
Human tissue
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
21. Human tissue LOCATION_OF TMPRSS2 gene|TMPRSS2
Subject
Human tissue
Predicate
LOCATION_OF
Object
TMPRSS2 gene|TMPRSS2
22. TMPRSS2 gene|TMPRSS2 AFFECTS Malignant neoplasm of prostate
Subject
TMPRSS2 gene|TMPRSS2
Predicate
AFFECTS
Object
Malignant neoplasm of prostate
23. Antiandrogen therapy METHOD_OF Androgen Suppression
Subject
Antiandrogen therapy
Predicate
METHOD_OF
Object
Androgen Suppression
24. Androgen Suppression TREATS Malignant neoplasm of prostate
Subject
Androgen Suppression
Predicate
TREATS
Object
Malignant neoplasm of prostate
25. Androgens INTERACTS_WITH angiotensin converting enzyme 2
Subject
Androgens
Predicate
INTERACTS_WITH
Object
angiotensin converting enzyme 2
26. Androgens INTERACTS_WITH TMPRSS2 gene|TMPRSS2
Subject
Androgens
Predicate
INTERACTS_WITH
Object
TMPRSS2 gene|TMPRSS2
27. Androgens INHIBITS TMPRSS2 gene|TMPRSS2
Subject
Androgens
Predicate
INHIBITS
Object
TMPRSS2 gene|TMPRSS2
28. Androgens TREATS 2019 novel coronavirus
Subject
Androgens
Predicate
TREATS
Object
2019 novel coronavirus
29. Androgens TREATS COVID-19
Subject
Androgens
Predicate
TREATS
Object
COVID-19
30. Androgens TREATS Malignant neoplasm of prostate
Subject
Androgens
Predicate
TREATS
Object
Malignant neoplasm of prostate
ABSTRACT
The current pandemic (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health challenge with active development of antiviral drugs and vaccines seeking to reduce its significant disease burden. Early reports have confirmed that transmembrane serine protease 2 (TMPRSS2) and angiotensin converting enzyme 2 (ACE2) are critical targets of SARS-CoV-2 that facilitate viral entry into host cells. TMPRSS2 and ACE2 are expressed in multiple human tissues beyond the lung including the testes where predisposition to SARS-CoV-2 infection may exist. TMPRSS2 is an androgen-responsive gene and its fusion represents one of the most frequent alterations in prostate cancer. Androgen suppression by androgen deprivation therapy and androgen receptor signaling inhibitors form the foundation of prostate cancer treatment. In this review, we highlight the growing evidence in support of androgen regulation of TMPRSS2 and ACE2 and the potential clinical implications of using androgen suppression to downregulate TMPRSS2 to target SARS-CoV-2. We also discuss the future directions and controversies that need to be addressed in order to establish the viability of targeting TMPRSS2 and/or ACE2 through androgen signaling regulation for COVID-19 treatment, particularly its relevance in the context of prostate cancer management.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Prostatic Neoplasms / Coronavirus Infections / Betacoronavirus / Androgen Antagonists Topics: Vaccines Limits: Humans / Male Language: English Journal: Endocr Relat Cancer Journal subject: Endocrinology / Neoplasms Year: 2020 Document Type: Article Affiliation country: ERC-20-0165

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Prostatic Neoplasms / Coronavirus Infections / Betacoronavirus / Androgen Antagonists Topics: Vaccines Limits: Humans / Male Language: English Journal: Endocr Relat Cancer Journal subject: Endocrinology / Neoplasms Year: 2020 Document Type: Article Affiliation country: ERC-20-0165