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Clonal haematopoiesis and COVID-19: A possible deadly liaison.
Shivarov, Velizar; Ivanova, Milena.
  • Shivarov V; Department of Clinical Hematology, Sofiamed University Hospital, Sofia, Bulgaria.
  • Ivanova M; Laboratory of Clinical Immunology, Sofiamed University Hospital, Sofia, Bulgaria.
Int J Immunogenet ; 47(4): 329-331, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-591799
ABSTRACT
We provide evidence for a linear correlation between the frequency of clonal haematopoiesis and COVID-19 mortality rate. We discuss the mechanistic explanations for this association mediated by a pathological inflammatory response. Our hypothesis can be tested in COVID-19-infected patients and eventually lead to new approaches to risk stratification and therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Aging / Coronavirus Infections / Clonal Selection, Antigen-Mediated / Hematopoiesis Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Immunogenet Journal subject: Allergy and Immunology / Genetics Year: 2020 Document Type: Article Affiliation country: Iji.12503

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Aging / Coronavirus Infections / Clonal Selection, Antigen-Mediated / Hematopoiesis Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Immunogenet Journal subject: Allergy and Immunology / Genetics Year: 2020 Document Type: Article Affiliation country: Iji.12503