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Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.
Jácome, Rodrigo; Campillo-Balderas, José Alberto; Ponce de León, Samuel; Becerra, Arturo; Lazcano, Antonio.
  • Jácome R; Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Campillo-Balderas JA; Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Ponce de León S; Programa Universitario de Investigación en Salud, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Becerra A; Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Lazcano A; Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico. alar@ciencias.unam.mx.
Sci Rep ; 10(1): 9294, 2020 06 09.
Article in English | MEDLINE | ID: covidwho-592060
ABSTRACT
As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside analog antiviral approved for hepatitis C virus infections, with the SARS-CoV polymerase shows that the residues that bind to the drug are present in the latter. Moreover, a multiple alignment of several SARS-CoV-2, SARS and MERS-related coronaviruses polymerases shows that these residues are conserved in all these viruses, opening the possibility to use sofosbuvir against these highly infectious pathogens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Coronavirus Infections / Pandemics / Sofosbuvir / Betacoronavirus Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-66440-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Coronavirus Infections / Pandemics / Sofosbuvir / Betacoronavirus Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-66440-9