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Evaluation of variation in D-dimer levels among COVID-19 and bacterial pneumonia: a retrospective analysis.
Yu, Bilian; Li, Xin; Chen, Jin; Ouyang, Mingqi; Zhang, Hong; Zhao, Xinge; Tang, Liang; Luo, Qin; Xu, Min; Yang, Lizhen; Huang, Guxiang; Liu, Xianling; Tang, Jianjun.
  • Yu B; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Li X; Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from the Second Xiangya Hospital, Central South University at Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.
  • Chen J; Department of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Ouyang M; Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from the Second Xiangya Hospital, Central South University at Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.
  • Zhang H; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Zhao X; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Tang L; Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Luo Q; Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from the Second Xiangya Hospital, Central South University at Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.
  • Xu M; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Yang L; Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from the Second Xiangya Hospital, Central South University at Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.
  • Huang G; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
  • Liu X; Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from the Second Xiangya Hospital, Central South University at Tongji Hospital of Tongji Medical College, Wuhan, Hubei, China.
  • Tang J; Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
J Thromb Thrombolysis ; 50(3): 548-557, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-592260
ABSTRACT
In the recent outbreak of novel coronavirus infection worldwide, the risk of thrombosis and bleeding should be concerned. We aimed to observe the dynamic changes of D-dimer levels during disease progression to evaluate their value for thrombosis. In this study, we report the clinical and laboratory results of 57 patients with confirmed COVID-19 pneumonia and 46 patients with confirmed community-acquired bacterial pneumonia (CAP). And their concentrations of D-dimer, infection-related biomarkers, and conventional coagulation were retrospectively analyzed. The Padua prediction score is used to identify patients at high risk for venous thromboembolism (VTE). The results found that, on admission, both in COVID-19 patients and CAP patients, D-dimer levels were significantly increased, and compared with CAP patients, D-dimer levels were higher in COVID-19 patients (P < 0.05). Besides, we found that in COVID-19 patients, D-dimer were related with markers of inflammation, especially with hsCRP (R = 0.426, P < 0.05). However, there was low correlation between VTE score and D-dimer levels (Spearman's R = 0.264, P > 0.05) weakened the role of D-dimer in the prediction of thrombosis. After treatments, D-dimer levels decreased which was synchronous with hsCRP levels in patients with good clinical prognosis, but there were still some patients with anomalous increasing D-dimer levels after therapy. In conclusion, elevated baseline D-dimer levels are associated with inflammation but not with VTE score in COVID-19 patients, suggesting that it is unreasonable to judge whether anticoagulation is needed only according to D-dimer levels. However, the abnormal changes of D-dimer and inflammatory factors suggest that anticoagulant therapy might be needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Fibrin Fibrinogen Degradation Products / Coronavirus Infections / Pneumonia, Bacterial / Venous Thromboembolism / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: S11239-020-02171-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Fibrin Fibrinogen Degradation Products / Coronavirus Infections / Pneumonia, Bacterial / Venous Thromboembolism / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Thromb Thrombolysis Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: S11239-020-02171-y