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COVID 19: a clue from innate immunity.
Birra, Domenico; Benucci, Maurizio; Landolfi, Luigi; Merchionda, Anna; Loi, Gabriella; Amato, Patrizia; Licata, Gaetano; Quartuccio, Luca; Triggiani, Massimo; Moscato, Paolo.
  • Birra D; UOC of Internal Medicine - Rheumatology Outpatients Unit, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, Salerno, Italy. dombirra@gmail.com.
  • Benucci M; Rheumatology Unit, S. Giovanni di Dio Hospital, Florence, Italy.
  • Landolfi L; UOC of Internal Medicine, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy.
  • Merchionda A; UOC of Internal Medicine - Rheumatology Outpatients Unit, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, Salerno, Italy.
  • Loi G; UOC of Internal Medicine - Rheumatology Outpatients Unit, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, Salerno, Italy.
  • Amato P; SERT, ASL Salerno, Salerno, Italy.
  • Licata G; Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Quartuccio L; Clinic of Rheumatology, Department of Medicine (DAME), ASUFC, University of Udine, Udine, Italy.
  • Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Fisciano, Italy.
  • Moscato P; UOC of Internal Medicine - Rheumatology Outpatients Unit, Azienda Ospedaliero-Universitaria San Giovanni di Dio e Ruggi D'Aragona, Via San Leonardo 1, Salerno, Italy.
Immunol Res ; 68(3): 161-168, 2020 06.
Article in English | MEDLINE | ID: covidwho-592322
ABSTRACT
The recent COVID-19 pandemic has had a significant impact on our lives and has rapidly expanded to reach more than 4 million cases worldwide by May 2020. These cases are characterized by extreme variability, from a mild or asymptomatic form lasting for a few days up to severe forms of interstitial pneumonia that may require ventilatory therapy and can lead to patient death.Several hypotheses have been drawn up to understand the role of the interaction between the infectious agent and the immune system in the development of the disease and the most severe forms; the role of the cytokine storm seems important.Innate immunity, as one of the first elements of guest interaction with different infectious agents, could play an important role in the development of the cytokine storm and be responsible for boosting more severe forms. Therefore, it seems important to study also this important arm of the immune system to adequately understand the pathogenesis of the disease. Research on this topic is also needed to develop therapeutic strategies for treatment of this disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome / Immunity, Innate Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Immunol Res Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: S12026-020-09137-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome / Immunity, Innate Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Immunol Res Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: S12026-020-09137-5