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COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination.
Boziki, Marina Kleopatra; Mentis, Alexios-Fotios A; Shumilina, Maria; Makshakov, Gleb; Evdoshenko, Evgeniy; Grigoriadis, Nikolaos.
  • Boziki MK; 2nd Neurological University Department, AHEPA General Hospital, Aristotle University of Thessaloniki, 54634 Thessaloniki, Greece.
  • Mentis AA; Public Health Laboratories, Hellenic Pasteur Institute, 11521 Athens, Greece.
  • Shumilina M; Laboratory of Microbiology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41110 Larissa, Greece.
  • Makshakov G; SPb Multiple Sclerosis Centre, Dinamo pr 11, St. Petersburg 197110, Russia.
  • Evdoshenko E; SPb Multiple Sclerosis Centre, Dinamo pr 11, St. Petersburg 197110, Russia.
  • Grigoriadis N; SPb Multiple Sclerosis Centre, Dinamo pr 11, St. Petersburg 197110, Russia.
Brain Sci ; 10(6)2020 Jun 04.
Article in English | MEDLINE | ID: covidwho-593070
ABSTRACT
In the frame of the coronavirus disease 2019 (COVID-19) pandemic, recent reports on SARS-CoV-2 potential neuroinvasion placed neurologists on increased alertness in order to assess early neurological manifestations and their potentially prognostic value for the COVID-19 disease. Moreover, the management of chronic neurological diseases, such as Multiple Sclerosis (MS), underwent guided modifications, such as an Extended Interval Dose (EID) of Disease-Modifying Treatment (DMT) administration, in order to minimize patients' exposure to the health system, thus reducing the risk of SARS-CoV-2 infection. In this review, we summarize existing evidence of key immune pathways that the SARS-CoV-2 modifies during COVID-19 and the relevant implication for MS and other autoimmune diseases with associated demyelination (such as Systemic lupus erythematosus and Antiphospholipid syndrome), including the context of potential neuroinvasion by SARS-Cov-2 and the alterations that DMT induces to the immune system. Moreover we hereby aim to provide an overview of the possible consequences that COVID-19 may carry for the Central Nervous System (CNS) in People with MS (PwMS) and other demyelinating diseases, which are likely to pose challenges for treating Neurologists with respect to the long-term disease management of these diseases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Brainsci10060345

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: Brainsci10060345