Potential for jaktinib hydrochloride to treat cytokine storms in patients with COVID-19.
Biosci Trends
; 14(3): 161-167, 2020 Jul 17.
Article
in English
| MEDLINE | ID: covidwho-593589
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a serious public health threat to the whole world, and the number of infected is still rising dramatically at this moment. Several studies have confirmed that cytokine storms play a critical role in causing a case to worsen from mild to severe or critical. The current treatment for cytokine storms is limited, so the international medical community is focusing on a specific and effective remedy. Jaktinib hydrochloride is a broad spectrum JAK inhibitor. It can inhibit cytokine-induced immune activation by multiple mechanisms and also slow viral proliferation by inhibiting AAK1 without causing unacceptable toxicity. Jaktinib hydrochloride has great potential for the treatment of patients with coronavirus disease 2019 (COVID-19).
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Janus Kinase Inhibitors
Limits:
Humans
Language:
English
Journal:
Biosci Trends
Journal subject:
Biology
Year:
2020
Document Type:
Article
Affiliation country:
Bst.2020.03106
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