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Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital.
Ramcharan, Tristan; Nolan, Oscar; Lai, Chui Yi; Prabhu, Nanda; Krishnamurthy, Raghu; Richter, Alex G; Jyothish, Deepthi; Kanthimathinathan, Hari Krishnan; Welch, Steven B; Hackett, Scott; Al-Abadi, Eslam; Scholefield, Barnaby R; Chikermane, Ashish.
  • Ramcharan T; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK.
  • Nolan O; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK.
  • Lai CY; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK.
  • Prabhu N; Department of Cardiology, Birmingham Women's and Children's NHS Foundation Trust, Steelhouse Lane, Birmingham, B4 6NH, UK.
  • Krishnamurthy R; Department of Paediatrics, Manor Hospital, Walsall, WS2 9PS, UK.
  • Richter AG; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Jyothish D; Department of Paediatrics, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B4 6NH, UK.
  • Kanthimathinathan HK; Paediatric Intensive Care Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B4 6NH, UK.
  • Welch SB; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK.
  • Hackett S; Department of Paediatrics, Birmingham Chest Clinic and Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B9 5SS, UK.
  • Al-Abadi E; Department of Paediatrics, Birmingham Chest Clinic and Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B9 5SS, UK.
  • Scholefield BR; Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK.
  • Chikermane A; Childhood Arthritis and Rheumatic Diseases Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B4 6NH, UK.
Pediatr Cardiol ; 41(7): 1391-1401, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-593665
Semantic information from SemMedBD (by NLM)
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2. 2019 novel coronavirus COEXISTS_WITH Mucocutaneous Lymph Node Syndrome
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2019 novel coronavirus
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Mucocutaneous Lymph Node Syndrome
3. 2019 novel coronavirus COEXISTS_WITH Toxic Shock Syndrome
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4. PIM1 gene|PIM1 PART_OF Child
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PIM1 gene|PIM1
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Child
5. Cardiac finding PROCESS_OF Child
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Cardiac finding
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Child
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7. PIM1 gene|PIM1 PART_OF Cohort
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8. Tertiary Care Centers LOCATION_OF Administration occupational activities
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LOCATION_OF
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Administration occupational activities
9. 2019 novel coronavirus COEXISTS_WITH Mucocutaneous Lymph Node Syndrome
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2019 novel coronavirus
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Mucocutaneous Lymph Node Syndrome
10. 2019 novel coronavirus COEXISTS_WITH Toxic Shock Syndrome
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Child
12. Cardiac finding PROCESS_OF Child
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Child
13. Present PROCESS_OF Patients
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PROCESS_OF
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ABSTRACT
Children were relatively spared during COVID-19 pandemic. However, the recently reported hyperinflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome-"Paediatric Inflammatory Multisystem Syndrome-temporally associated with SARS-CoV-2" (PIMS-TS) has caused concern. We describe cardiac findings and short-term outcomes in children with PIMS-TS at a tertiary children's hospital. Single-center observational study of children with PIMS-TS from 10th April to 9th May 2020. Data on ECG and echocardiogram were retrospectively analyzed along with demographics, clinical features and blood parameters. Fifteen children with median age of 8.8 (IQR 6.4-11.2) years were included, all were from African/Afro-Caribbean, South Asian, Mixed or other minority ethnic groups. All showed raised inflammatory/cardiac markers (CRP, ferritin, Troponin I, CK and pro-BNP). Transient valve regurgitation was present in 10 patients (67%). Left Ventricular ejection fraction was reduced in 12 (80%), fractional shortening in 8 (53%) with resolution in all but 2. Fourteen (93%) had coronary artery abnormalities, with normalization in 6. ECG abnormalities were present in 9 (60%) which normalized in 6 by discharge. Ten (67%) needed inotropes and/or vasopressors. None needed extracorporeal life support. Improvement in cardiac biochemical markers was closely followed by improvement in ECG/echocardiogram. All patients were discharged alive and twelve (80%) have been reviewed since. Our entire cohort with PIMS-TS had cardiac involvement and this degree of involvement is significantly more than other published series and emphasizes the need for specialist cardiac review. We believe that our multi-disciplinary team approach was crucial for the good short-term outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome / Heart Diseases / Hospitals, Pediatric Type of study: Observational study / Randomized controlled trials / Risk factors Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Pediatr Cardiol Year: 2020 Document Type: Article Affiliation country: S00246-020-02391-2

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome / Heart Diseases / Hospitals, Pediatric Type of study: Observational study / Randomized controlled trials / Risk factors Limits: Child / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Pediatr Cardiol Year: 2020 Document Type: Article Affiliation country: S00246-020-02391-2