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Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine.
Bonam, Srinivasa Reddy; Muller, Sylviane; Bayry, Jagadeesh; Klionsky, Daniel J.
  • Bonam SR; Institut National de la Santé et de la Recherche Médicale; Centre de Recherche des Cordeliers, Equipe- Immunopathologie et Immunointervention Thérapeutique, Sorbonne Université, Université De Paris , Paris, France.
  • Muller S; CNRS and Strasbourg University Unit Biotechnology and Cell signalling / Laboratory of excellence Medalis , Strasbourg, France.
  • Bayry J; Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg University , Strasbourg, France.
  • Klionsky DJ; Chair of Therapeutic Immunology, University of Strasbourg Institute for Advanced Study (USIAS) , Strasbourg, France.
Autophagy ; 16(12): 2260-2266, 2020 12.
Article in English | MEDLINE | ID: covidwho-593676
Semantic information from SemMedBD (by NLM)
1. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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Patients
3. hydroxychloroquine TREATS Patients
Subject
hydroxychloroquine
Predicate
TREATS
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Patients
4. hydroxychloroquine TREATS Severe Acute Respiratory Syndrome
Subject
hydroxychloroquine
Predicate
TREATS
Object
Severe Acute Respiratory Syndrome
5. hydroxychloroquine TREATS COVID-19
Subject
hydroxychloroquine
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TREATS
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COVID-19
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. hydroxychloroquine TREATS Patients
Subject
hydroxychloroquine
Predicate
TREATS
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Patients
8. hydroxychloroquine TREATS Severe Acute Respiratory Syndrome
Subject
hydroxychloroquine
Predicate
TREATS
Object
Severe Acute Respiratory Syndrome
ABSTRACT
During the last week of December 2019, Wuhan (China) was confronted with the first case of respiratory tract disease 2019 (coronavirus disease 2019, COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the rapid outbreak of the transmission (~3.64 million positive cases and high mortality as of 5 May 2020), the world is looking for immediate and better therapeutic options. Still, much information is not known, including origin of the disease, complete genomic characterization, mechanism of transmission dynamics, extent of spread, possible genetic predisposition, clinical and biological diagnosis, complete details of disease-induced pathogenicity, and possible therapeutic options. Although several known drugs are already under clinical evaluation with many in repositioning strategies, much attention has been paid to the aminoquinoline derivates, chloroquine (CQ) and hydroxychloroquine (HCQ). These molecules are known regulators of endosomes/lysosomes, which are subcellular organelles central to autophagy processes. By elevating the pH of acidic endosomes/lysosomes, CQ/HCQ inhibit the autophagic process. In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.Abbreviation ACE2 angiotensin I converting enzyme 2; CoV coronavirus; CQ chloroquine; ER endoplasmic reticulum; HCQ hydroxychloroquine; MERS-CoV Middle East respiratory syndrome coronavirus; SARS-CoV severe acute respiratory syndrome coronavirus; SARS-CoV-2 severe acute respiratory syndrome coronavirus 2.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Chloroquine / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Autophagy Year: 2020 Document Type: Article Affiliation country: 15548627.2020.1779467

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autophagy / Chloroquine / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Autophagy Year: 2020 Document Type: Article Affiliation country: 15548627.2020.1779467