Is Albumin Predictor of Mortality in COVID-19?
Antioxid Redox Signal
; 35(2): 139-142, 2021 07 10.
Article
in English
| MEDLINE | ID: covidwho-593682
ABSTRACT
Coronavirus 2019 (COVID-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant property; however, its behavior and impact on survival in COVID-19 patients have never been studied so far. Among 319 COVID-19 patients followed up for a median of 19 days, 64 died. Compared with survivors, nonsurvivors had more prevalence of intensive care unit (ICU) admission, chronic obstructive pulmonary disease (COPD), heart failure, elevated levels of D-dimer, high-sensitivity C reactive protein (hs-CRP) and troponins, and lower values of albumin. At the Cox regression analysis, albumin (hazard ratio [HR] 0.38, 95% confidence interval [CI] 0.23-0.63, p < 0.001) and age (HR 1.03, 95% CI 1.01-1.06, p = 0.001) were independently associated with mortality, irrespective of adjustment for gender, ICU admission, heart failure, COPD, and hs-CRP levels. Our observation leads to the hypothesis that HSA analysis may be used to identify patients at higher risk of death in COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Antioxid Redox Signal
Journal subject:
Metabolism
Year:
2021
Document Type:
Article
Affiliation country:
Ars.2020.8142
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