Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
Eurosurveillance
; 25(23), 2020.
Article
in English
| GIM | ID: covidwho-1716875
ABSTRACT
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
308067-58-5; antibodies; diagnosis; diagnostic techniques; human diseases; IgG; IgM; immunoassay; meta-analysis; seroconversion; serology; techniques; viral diseases; man; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Coronavirus disease; Covid-19; Severe acute respiratory syndrome coronavirus 2; viral infections
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Diagnostic study
/
Reviews
Language:
English
Journal:
Eurosurveillance
Year:
2020
Document Type:
Article
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