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Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications
Eurosurveillance ; 25(23), 2020.
Article in English | GIM | ID: covidwho-1716875
ABSTRACT
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
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Collection: Databases of international organizations Database: GIM Type of study: Diagnostic study / Reviews Language: English Journal: Eurosurveillance Year: 2020 Document Type: Article

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Collection: Databases of international organizations Database: GIM Type of study: Diagnostic study / Reviews Language: English Journal: Eurosurveillance Year: 2020 Document Type: Article