Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications.
Gen Physiol Biophys
; 39(3): 203-204, 2020 May.
Article
in English
| MEDLINE | ID: covidwho-595142
ABSTRACT
Renin-angiotensin system (RAS) inhibition supposedly increases the expression of angiotensin converting enzyme 2, serving as a binding site for SARS-CoV-2. Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. However, the pharmacological restraining the classical RAS axis might be beneficial due to the reduction of deleterious effects of angiotensin II and enhancement of the anti-inflammatory angiotensin 1-7 pathway. Unless large controlled studies are performed, RAS inhibition remains the cornerstone therapy in populations with cardiovascular disorders.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Renin-Angiotensin System
/
Cardiovascular Diseases
/
Coronavirus Infections
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Gen Physiol Biophys
Year:
2020
Document Type:
Article
Affiliation country:
Gpb_2020019
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