Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection.

de Maat, Steven; de Mast, Quirijn; Danser, A H Jan; van de Veerdonk, Frank L; Maas, Coen

de Maat, Steven; de Mast, Quirijn; Danser, A H Jan; van de Veerdonk, Frank L; Maas, Coen.

de Maat S; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
de Mast Q; Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Danser AHJ; Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus MC, Rotterdam, The Netherlands.
van de Veerdonk FL; Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Maas C; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Semin Thromb Hemost ; 46(7): 835-837, 2020 10.

Article in English | MEDLINE | ID: covidwho-596079

Subject(s)

Betacoronavirus; Bradykinin/metabolism; Coronavirus Infections/complications; Pandemics; Pneumonia, Viral/complications; Pulmonary Edema/etiology; Angiotensin II/physiology; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; Bradykinin/analogs & derivatives; COVID-19; Chick Embryo; Coronavirus Infections/metabolism; Disease Models, Animal; Humans; Kininogens/metabolism; Mice; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/metabolism; Renin-Angiotensin System/physiology; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Edema / Bradykinin / Coronavirus Infections / Pandemics / Betacoronavirus Topics: Long Covid Limits: Animals / Humans Language: English Journal: Semin Thromb Hemost Year: 2020 Document Type: Article Affiliation country: S-0040-1712960

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