Coronavirus Infections/therapy; Pneumonia, Viral/therapy; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/therapeutic use; Antibodies, Neutralizing/immunology; Antibodies, Neutralizing/therapeutic use; Antiviral Agents/therapeutic use; Betacoronavirus/isolation & purification; Betacoronavirus/metabolism; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/virology; Cytokines/antagonists & inhibitors; Cytokines/metabolism; DNA-Directed RNA Polymerases/antagonists & inhibitors; DNA-Directed RNA Polymerases/metabolism; Drug Repositioning; Humans; Immune System/metabolism; Nitriles; Pandemics; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; Pyrazoles/chemistry; Pyrazoles/metabolism; Pyrazoles/therapeutic use; Pyrimidines; SARS-CoV-2