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Clinical features of COVID-19 convalescent patients with re-positive nucleic acid detection.
Zhu, Hui; Fu, Liyun; Jin, Yinhua; Shao, Jiale; Zhang, Shun; Zheng, Nanhong; Fan, Lingyan; Yu, Zhe; Ying, Jun; Hu, Yaoren; Chen, Tongen; Chen, Yanglingzi; Chen, Min; Chen, Mingjue; Xiong, Zi; Kang, Junfei; Jin, Jiachang; Cai, Ting; Ye, Honghua.
  • Zhu H; Department of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Fu L; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
  • Jin Y; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
  • Shao J; Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Zhang S; Department of Radiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Zheng N; Department of Respiratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Fan L; Department of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Yu Z; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
  • Ying J; Department of Acute Infection, HwaMei Hospital University of Chinese Academy of Sciences, Ningbo, China.
  • Hu Y; Department of Acute Infection, HwaMei Hospital University of Chinese Academy of Sciences, Ningbo, China.
  • Chen T; Department of Respiratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Chen Y; Department of Respiratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Chen M; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
  • Chen M; Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Xiong Z; Department of General practice, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Kang J; Department of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Jin J; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
  • Cai T; Department of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
  • Ye H; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China.
J Clin Lab Anal ; 34(7): e23392, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-596675
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is a pandemic that has rapidly spread worldwide. Increasingly, confirmed patients being discharged according to the current diagnosis and treatment protocols, follow-up of convalescent patients is important to knowing about the outcome.

METHODS:

A retrospective study was performed among 98 convalescent patients with COVID-19 in a single medical center. The clinical features of patients during their hospitalization and 2-week postdischarge quarantine were collected.

RESULTS:

Among the 98 COVID-19 convalescent patients, 17 (17.3%) were detected positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid during 2-week postdischarge quarantine. The median time from discharge to SARS-CoV-2 nucleic acid re-positive was 4 days (IQR, 3-8.5).The median time from symptoms onset to final respiratory SARS-CoV-2 detection of negative result was significantly longer in re-positive group (34 days [IQR, 29.5-42.5]) than in non-re-positive group (19 days [IQR, 16-26]). On the other hand, the levels of CD3-CD56 + NK cells during hospitalization and 2-week postdischarge were higher in re-positive group than in non-re-positive group (repeated measures ANOVA, P = .018). However, only one case in re-positive group showed exudative lesion recurrence in pulmonary computed tomography (CT) with recurred symptoms.

CONCLUSION:

It is still possible for convalescent patients to show positive for SARS-CoV-2 nucleic acid detection, but most of the re-positive patients showed no deterioration in pulmonary CT findings. Continuous quarantine and close follow-up for convalescent patients are necessary to prevent possible relapse and spread of the disease to some extent.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Nucleic Acids / Convalescence / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Clin Lab Anal Journal subject: Laboratory Techniques and procedures Year: 2020 Document Type: Article Affiliation country: Jcla.23392

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Nucleic Acids / Convalescence / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Clin Lab Anal Journal subject: Laboratory Techniques and procedures Year: 2020 Document Type: Article Affiliation country: Jcla.23392