NK cells: A double edge sword against SARS-CoV-2.
Adv Biol Regul
; 77: 100737, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-597242
ABSTRACT
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual from microbes. They are the first line of defense against invading viruses, given their substantial ability to directly target infected cells without the need for specific antigen presentation. By establishing cellular networks with a variety of cell types such as dendritic cells, NK cells can also amplify and modulate antiviral adaptive immune responses. In this review, we will examine the role of NK cells in SARS-COV2 infections causing the ongoing COVID19 pandemic, keeping in mind the controversial role of NK cells specifically in viral respiratory infections and in inflammatory-driven lung damage. We discuss lessons learnt from previous coronavirus outbreaks in humans (caused by SARS-CoV-1 and MERS-COV).
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Respiratory Insufficiency
/
Killer Cells, Natural
/
Coronavirus Infections
/
Host-Pathogen Interactions
/
Pandemics
/
Betacoronavirus
Type of study:
Diagnostic study
/
Observational study
Topics:
Long Covid
Language:
English
Journal:
Adv Biol Regul
Year:
2020
Document Type:
Article
Affiliation country:
J.jbior.2020.100737
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