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Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach.
Naqvi, Ahmad Abu Turab; Fatima, Kisa; Mohammad, Taj; Fatima, Urooj; Singh, Indrakant K; Singh, Archana; Atif, Shaikh Muhammad; Hariprasad, Gururao; Hasan, Gulam Mustafa; Hassan, Md Imtaiyaz.
  • Naqvi AAT; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
  • Fatima K; Department of Biotechnology, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
  • Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
  • Fatima U; Department of Botany, Aligarh Muslim University, Aligarh 202002, U.P., India.
  • Singh IK; Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, New Delhi 110 019, India.
  • Singh A; Department of Botany, Hansraj College, University of Delhi, Delhi, 110007, India.
  • Atif SM; Department of Medicine, University of Colorado, Aurora, CO, USA.
  • Hariprasad G; Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.
  • Hasan GM; Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
  • Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: mihassan@jmi.ac.in.
Biochim Biophys Acta Mol Basis Dis ; 1866(10): 165878, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-597413
ABSTRACT
The sudden emergence of severe respiratory disease, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently become a public health emergency. Genome sequence analysis of SARS-CoV-2 revealed its close resemblance to the earlier reported SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). However, initial testing of the drugs used against SARS-CoV and MERS-CoV has been ineffective in controlling SARS-CoV-2. The present study highlights the genomic, proteomic, pathogenesis, and therapeutic strategies in SARS-CoV-2 infection. We have carried out sequence analysis of potential drug target proteins in SARS-CoV-2 and, compared them with SARS-CoV and MERS viruses. Analysis of mutations in the coding and non-coding regions, genetic diversity, and pathogenicity of SARS-CoV-2 has also been done. A detailed structural analysis of drug target proteins has been performed to gain insights into the mechanism of pathogenesis, structure-function relationships, and the development of structure-guided therapeutic approaches. The cytokine profiling and inflammatory signalling are different in the case of SARS-CoV-2 infection. We also highlighted possible therapies and their mechanism of action followed by clinical manifestation. Our analysis suggests a minimal variation in the genome sequence of SARS-CoV-2, may be responsible for a drastic change in the structures of target proteins, which makes available drugs ineffective.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Document Type: Article Affiliation country: J.bbadis.2020.165878

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Biochim Biophys Acta Mol Basis Dis Year: 2020 Document Type: Article Affiliation country: J.bbadis.2020.165878