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Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.
Guallar, María Pilar; Meiriño, Rosa; Donat-Vargas, Carolina; Corral, Octavio; Jouvé, Nicolás; Soriano, Vicente.
  • Guallar MP; Department of Preventive Medicine, Public Health & Microbiology. Medical School. Universidad Autónoma de Madrid, Madrid, Spain; IdiPAZ & CIBER Epidemiology & Public Health (CIBERESP) & IMDEA-Food Institute, CEI UAM-CSIC, Madrid, Spain.
  • Meiriño R; Oncology Department, Clínica Universitaria de Navarra, Madrid, Spain.
  • Donat-Vargas C; Department of Preventive Medicine, Public Health & Microbiology. Medical School. Universidad Autónoma de Madrid, Madrid, Spain; Nutritional and Cardiovascular Epidemiology Unit, Environmental Medicine Institute (IMM), Karolinska Institute, Stockholm, Sweden.
  • Corral O; Genetics Department, Alcalá University, Madrid, Spain.
  • Jouvé N; Genetics Department, Alcalá University, Madrid, Spain.
  • Soriano V; Medical Center & Health Sciences School, UNIR, Madrid, Spain. Electronic address: vicente.soriano@unir.net.
Int J Infect Dis ; 97: 290-292, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-597415
ABSTRACT
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Viral Load Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.06.035

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Viral Load Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.06.035