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Development of child immunity in the context of COVID-19 pandemic.
Kloc, Malgorzata; Ghobrial, Rafik M; Kuchar, Ernest; Lewicki, Slawomir; Kubiak, Jacek Z.
  • Kloc M; The Houston Methodist Research Institute, Houston, TX, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA; The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston, TX, USA. Electronic address: mkloc@houstonmethodist.org.
  • Ghobrial RM; The Houston Methodist Research Institute, Houston, TX, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA.
  • Kuchar E; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Poland.
  • Lewicki S; Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland.
  • Kubiak JZ; Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland; UnivRennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Cell Cycle Group, Faculty of Medicine, Rennes, France. Electronic address: jacek.kubiak@univ-renne
Clin Immunol ; 217: 108510, 2020 08.
Article in English | MEDLINE | ID: covidwho-597611
ABSTRACT
Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. We discuss here what are the main features and components of children's immune system, the role of maternal transmission of immunity, and what are the possible explanations for the seemingly lower infection rate and severity of COVI-19 in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Immune System Type of study: Observational study / Prognostic study Limits: Adult / Child / Child, preschool / Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Immune System Type of study: Observational study / Prognostic study Limits: Adult / Child / Child, preschool / Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article