Molecular pharmacology of ciclesonide against SARS-CoV-2.

Kimura, Hirokazu; Kurusu, Hiromu; Sada, Mitsuru; Kurai, Daisuke; Murakami, Koichi; Kamitani, Wataru; Tomita, Haruyoshi; Katayama, Kazuhiko; Ryo, Akihide

Kimura, Hirokazu; Kurusu, Hiromu; Sada, Mitsuru; Kurai, Daisuke; Murakami, Koichi; Kamitani, Wataru; Tomita, Haruyoshi; Katayama, Kazuhiko; Ryo, Akihide.

Kimura H; Department of Health Science, Gunma Paz University Graduate School of Health Sciences, Gunma, Japan. Electronic address: kimhiro@nih.go.jp.
Kurusu H; Advanced Medical Science Research Center, Gunma Paz University, Gunma, Japan.
Sada M; Advanced Medical Science Research Center, Gunma Paz University, Gunma, Japan.
Kurai D; Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Murakami K; Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.
Kamitani W; Department of Infectious Diseases and Host Defense, Gunma University Graduate School of Medicine, Gunma, Japan.
Tomita H; Department of Bacteriology, Gunma University Graduate School of Medicine, Gunma, Japan.
Katayama K; Laboratory of Viral Infection I, Kitasato Institute for Life Sciences Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Ryo A; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, Japan.

J Allergy Clin Immunol ; 146(2): 330-331, 2020 08.

Article in English | MEDLINE | ID: covidwho-597639

Subject(s)

Antiviral Agents/pharmacology; Betacoronavirus/drug effects; Endoribonucleases/antagonists & inhibitors; Glucocorticoids/pharmacology; Pregnenediones/pharmacology; Viral Nonstructural Proteins/antagonists & inhibitors; Virus Replication/drug effects; Antiviral Agents/chemistry; Antiviral Agents/metabolism; Betacoronavirus/enzymology; Betacoronavirus/genetics; Binding Sites; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/virology; Endoribonucleases/chemistry; Endoribonucleases/genetics; Endoribonucleases/metabolism; Gene Expression; Glucocorticoids/chemistry; Glucocorticoids/metabolism; Humans; Molecular Dynamics Simulation; Pandemics; Pneumonia, Viral/drug therapy; Pneumonia, Viral/virology; Pregnenediones/chemistry; Pregnenediones/metabolism; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/genetics; RNA-Dependent RNA Polymerase/metabolism; SARS-CoV-2; Structural Homology, Protein; Thermodynamics; Viral Nonstructural Proteins/chemistry; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/metabolism

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pregnenediones / Virus Replication / Viral Nonstructural Proteins / Endoribonucleases / Betacoronavirus / Glucocorticoids Language: English Journal: J Allergy Clin Immunol Year: 2020 Document Type: Article

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