Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia.
Am J Infect Control
; 49(1): 82-89, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-597653
ABSTRACT
OBJECTIVE:
We aimed to investigate the relationship between clinical characteristics, outcomes and the severity of severe acute respiratory syndrome coronavirus 2 pneumonia.METHODS:
We performed a systematic review and meta-analysis using PubMed, Embase, and Cochrane Library databases to assess the clinical characteristics and outcomes of confirmed COVID-19 cases and compared severe (ICU) and nonsevere (non-ICU) groups.RESULTS:
We included 12 cohort studies including 2,445 patients with COVID-19. Compared with nonsevere (non-ICU) patients, severe (ICU) disease was associated with a smoking history (Pâ¯=â¯.003) and comorbidities including chronic obstructive pulmonary disease (ORâ¯=â¯5.08, P < .001), diabetes (ORâ¯=â¯3.17, P < .001), hypertension (ORâ¯=â¯2.40, P < .001), coronary heart disease (ORâ¯=â¯2.66, P < .001), cerebrovascular diseases (ORâ¯=â¯2.68, Pâ¯=â¯.008), and malignancy (OR=2.21, Pâ¯=â¯.040). We found significant differences between the 2 groups for fever, dyspnea, decreased lymphocyte and platelet counts, and increased leukocyte count, C-creative protein, procalcitonin, lactose dehydrogenase, aspartate aminotransferase, alanine aminotransferase, creatinine kinase, and creatinine levels (P < .05). Significant differences were also observed for multiple treatments (P < .05). Patients in the severe (ICU) group were more likely to have complications and had a much higher mortality rate and lower discharge rate than those with nonsevere (non-ICU) disease (P < .05).CONCLUSIONS:
Investigation of clinical characteristics and outcomes of severe cases of COVID-19 will contribute to early prediction, accurate diagnosis, and treatment to improve the prognosis of patients with severe illness.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Thrombocytopenia
/
Dyspnea
/
Fever
/
COVID-19
/
Leukocytosis
/
Lymphopenia
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Am J Infect Control
Year:
2021
Document Type:
Article
Affiliation country:
J.ajic.2020.06.008
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