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Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.
Herzig, Volker; Cristofori-Armstrong, Ben; Israel, Mathilde R; Nixon, Samantha A; Vetter, Irina; King, Glenn F.
  • Herzig V; School of Science & Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia. Electronic address: vherzig@usc.edu.au.
  • Cristofori-Armstrong B; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
  • Israel MR; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
  • Nixon SA; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
  • Vetter I; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
  • King GF; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia. Electronic address: glenn.king@imb.uq.edu.au.
Biochem Pharmacol ; 181: 114096, 2020 11.
Article in English | MEDLINE | ID: covidwho-597939
Semantic information from SemMedBD (by NLM)
1. Toxin COEXISTS_WITH CAPTURE
Subject
Toxin
Predicate
COEXISTS_WITH
Object
CAPTURE
2. Disease PROCESS_OF Homo sapiens
Subject
Disease
Predicate
PROCESS_OF
Object
Homo sapiens
3. Toxin COEXISTS_WITH CAPTURE
Subject
Toxin
Predicate
COEXISTS_WITH
Object
CAPTURE
4. Disease PROCESS_OF Homo sapiens
Subject
Disease
Predicate
PROCESS_OF
Object
Homo sapiens
ABSTRACT
Venomous animals have evolved toxins that interfere with specific components of their victim's core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other roles such as intraspecific competition. Many animal lineages evolved venom systems independently, highlighting the success of this strategy. Over the course of evolution, toxins with exceptional specificity and high potency for their intended molecular targets have prevailed, making venoms an invaluable and almost inexhaustible source of bioactive molecules, some of which have found use as pharmacological tools, human therapeutics, and bioinsecticides. Current biomedically-focused research on venoms is directed towards their use in delineating the physiological role of toxin molecular targets such as ion channels and receptors, studying or treating human diseases, targeting vectors of human diseases, and treating microbial and parasitic infections. We provide examples of each of these areas of venom research, highlighting the potential that venom molecules hold for basic research and drug development.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptides / Toxins, Biological / Venoms / Biomedical Research / Drug Discovery Limits: Animals / Humans Language: English Journal: Biochem Pharmacol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptides / Toxins, Biological / Venoms / Biomedical Research / Drug Discovery Limits: Animals / Humans Language: English Journal: Biochem Pharmacol Year: 2020 Document Type: Article