Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana.

Pandeya, K B; Ganeshpurkar, Aditya; Mishra, Mahendra Kumar

Pandeya, K B; Ganeshpurkar, Aditya; Mishra, Mahendra Kumar.

Pandeya KB; Mahatma Gandhi Chitrakoot Gramodaya Vishwavidhyalaya, Chitrakoot, Satna (M.P.), India.
Ganeshpurkar A; Department of Pharmacology, Shri Ram Institute of Technology-Pharmacy, Jabalpur (M.P.), India. Electronic address: adityaganeshpurkar@gmail.com.
Mishra MK; Department of Botany, Government College Rehti, Sehore (M.P.), India. Electronic address: mahigene8611@gmail.com.

Med Hypotheses ; 144: 109905, 2020 Nov.

Article in English | MEDLINE | ID: covidwho-598356

ABSTRACT

ABSTRACT

COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed that Protopine, Allocryptopine and (±) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2.

Subject(s)

Argemone/chemistry; Benzophenanthridines/pharmacology; Berberine Alkaloids/pharmacology; COVID-19 Drug Treatment; Plant Extracts/therapeutic use; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Antiviral Agents/pharmacology; Computer Simulation; Drug Repositioning; Humans; Molecular Conformation; Molecular Docking Simulation; Phenanthrenes/pharmacology; Phytochemicals/pharmacology; Virus Replication/drug effects

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Berberine Alkaloids / RNA-Dependent RNA Polymerase / Plant Extracts / Argemone / Benzophenanthridines / COVID-19 Drug Treatment Limits: Humans Country/Region as subject: Mexico Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.109905

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