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Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study.
Qiu, Chenghao; Cui, Chong; Hautefort, Charlotte; Haehner, Antje; Zhao, Jun; Yao, Qi; Zeng, Hui; Nisenbaum, Eric J; Liu, Li; Zhao, Yu; Zhang, Di; Levine, Corinna G; Cejas, Ivette; Dai, Qi; Zeng, Mei; Herman, Philippe; Jourdaine, Clement; de With, Katja; Draf, Julia; Chen, Bing; Jayaweera, Dushyantha T; Denneny, James C; Casiano, Roy; Yu, Hongmeng; Eshraghi, Adrien A; Hummel, Thomas; Liu, Xuezhong; Shu, Yilai; Lu, Hongzhou.
  • Qiu C; Center of Stomatology, Shanghai Public Health Clinical Center, Shanghai, China.
  • Cui C; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Hautefort C; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  • Haehner A; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
  • Zhao J; Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
  • Yao Q; Center of Pediatrics, Shanghai Public Health Clinical Center, Shanghai, China.
  • Zeng H; Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Nisenbaum EJ; Department of Cardiovascularology, The Third People's Hospital of Shenzhen, Shenzhen, China.
  • Liu L; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Zhao Y; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, China.
  • Zhang D; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Levine CG; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  • Cejas I; Department of Otolaryngology, The Third People's Hospital of Shenzhen, Shenzhen, China.
  • Dai Q; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Zeng M; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Herman P; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Jourdaine C; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  • de With K; Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.
  • Draf J; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
  • Chen B; Department of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
  • Jayaweera DT; Division of Infectious Diseases, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany.
  • Denneny JC; Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
  • Casiano R; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Yu H; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
  • Eshraghi AA; Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Hummel T; American Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.
  • Liu X; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Shu Y; ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Lu H; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China.
Otolaryngol Head Neck Surg ; 163(4): 714-721, 2020 10.
Article in English | MEDLINE | ID: covidwho-999415
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ABSTRACT

OBJECTIVE:

To evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in coronavirus disease 2019 (COVID-19) patients. STUDY

DESIGN:

Multicenter case series.

SETTING:

Five tertiary care hospitals (3 in China, 1 in France, 1 in Germany). SUBJECTS AND

METHODS:

In total, 394 polymerase chain reaction (PCR)-confirmed COVID-19-positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and visual analog scale (VAS) were used to quantify olfactory and gustatory dysfunction, respectively. All subjects at 1 hospital (Shanghai) without subjective olfactory complaints underwent objective testing.

RESULTS:

Of 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n = 239), German (n = 39), and French (n = 116) cohorts was 32%, 69%, and 49%, respectively. The median age of included subjects was 39 years, 92 of 161 (57%) were male, and 10 of 161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10 of 90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. Forty-three percent (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation.

CONCLUSIONS:

Olfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Smell / Taste Disorders / Coronavirus Infections / Early Diagnosis / Betacoronavirus / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: Asia / Europa Language: English Journal: Otolaryngol Head Neck Surg Journal subject: Otolaryngology Year: 2020 Document Type: Article Affiliation country: 0194599820934376

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Smell / Taste Disorders / Coronavirus Infections / Early Diagnosis / Betacoronavirus / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: Asia / Europa Language: English Journal: Otolaryngol Head Neck Surg Journal subject: Otolaryngology Year: 2020 Document Type: Article Affiliation country: 0194599820934376