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Immunology of COVID-19: Current State of the Science.
Vabret, Nicolas; Britton, Graham J; Gruber, Conor; Hegde, Samarth; Kim, Joel; Kuksin, Maria; Levantovsky, Rachel; Malle, Louise; Moreira, Alvaro; Park, Matthew D; Pia, Luisanna; Risson, Emma; Saffern, Miriam; Salomé, Bérengère; Esai Selvan, Myvizhi; Spindler, Matthew P; Tan, Jessica; van der Heide, Verena; Gregory, Jill K; Alexandropoulos, Konstantina; Bhardwaj, Nina; Brown, Brian D; Greenbaum, Benjamin; Gümüs, Zeynep H; Homann, Dirk; Horowitz, Amir; Kamphorst, Alice O; Curotto de Lafaille, Maria A; Mehandru, Saurabh; Merad, Miriam; Samstein, Robert M.
  • Vabret N; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: nicolas.vabret@mssm.edu.
  • Britton GJ; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gruber C; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Hegde S; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kim J; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kuksin M; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Levantovsky R; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Malle L; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Moreira A; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Park MD; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Pia L; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Risson E; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Saffern M; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Salomé B; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Esai Selvan M; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Spindler MP; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tan J; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • van der Heide V; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gregory JK; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Alexandropoulos K; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bhardwaj N; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Brown BD; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Greenbaum B; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gümüs ZH; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Homann D; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Horowitz A; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kamphorst AO; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Curotto de Lafaille MA; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Mehandru S; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Merad M; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: miriam.merad@mssm.edu.
  • Samstein RM; Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: robert.samstein@mountsinai.org.
Immunity ; 52(6): 910-941, 2020 06 16.
Article in English | MEDLINE | ID: covidwho-599508
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2020 Document Type: Article