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SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure.
Thierry, Alain R; Roch, Benoit.
  • Thierry AR; Research Institute of Cancerology of Montpellier, INSERM U1194, IRCM, ICM, Université de Montpellier, Montpellier, F-34298, France.
  • Roch B; Respiratory Medicine, University Hospital of Montpellier, Montpellier Université, Montpellier, France.
Clin Sci (Lond) ; 134(12): 1295-1300, 2020 06 26.
Article in English | MEDLINE | ID: covidwho-599624
Semantic information from SemMedBD (by NLM)
1. COVID-19 CAUSES Symptoms
Subject
COVID-19
Predicate
CAUSES
Object
Symptoms
2. COVID-19 CAUSES Symptoms
Subject
COVID-19
Predicate
CAUSES
Object
Symptoms
ABSTRACT
We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease's symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Host-Pathogen Interactions / Extracellular Traps / Betacoronavirus Type of study: Risk factors Topics: Long Covid Limits: Humans Language: English Journal: Clin Sci (Lond) Year: 2020 Document Type: Article Affiliation country: CS20200531

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Host-Pathogen Interactions / Extracellular Traps / Betacoronavirus Type of study: Risk factors Topics: Long Covid Limits: Humans Language: English Journal: Clin Sci (Lond) Year: 2020 Document Type: Article Affiliation country: CS20200531