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Analysis of 2019 novel coronavirus infection and clinical characteristics of outpatients: An epidemiological study from a fever clinic in Wuhan, China.
Wei, Yanqiu; Lu, Yanjun; Xia, Liming; Yuan, Xianglin; Li, Gang; Li, Xinying; Liu, Li; Liu, Wenhua; Zhou, Peng; Wang, Cong-Yi; Zhang, Huilan.
  • Wei Y; Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Wuhan, China.
  • Lu Y; Department of Laboratory Medicine, Tongji Hospital, Wuhan, China.
  • Xia L; Department of Radiology, Tongji Hospital, Wuhan, China.
  • Yuan X; Department of Oncology, Tongji Hospital, Wuhan, China.
  • Li G; The Outpatient Office, Tongji Hospital, Wuhan, China.
  • Li X; Key Laboratory for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
  • Liu L; Key Laboratory for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
  • Liu W; Clinical Research Center, Tongji Hospital, Wuhan, China.
  • Zhou P; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Wang CY; The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Wuhan, China.
  • Zhang H; Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Wuhan, China.
J Med Virol ; 92(11): 2758-2767, 2020 11.
Article in English | MEDLINE | ID: covidwho-599691
ABSTRACT

BACKGROUND:

Since the outbreak of 2019 novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) pneumonia, thousands of patients with fever or cough were flocked into fever clinic of designated hospitals in Wuhan, China. To date, no data have ever been reported to reflect the prevalence of coronavirus disease 2019 (COVID-19) among these outpatients. Moreover, it is almost unknown to discriminate COVID-19 and nucleic acid negative patients based on clinical features in the fever clinics.

METHODS:

The infectious status of SARS-CoV-2 was estimated among the outpatients. The epidemiological and clinical characteristics were compared between COVID-19 and nucleic acid negative patients.

RESULTS:

The nucleic acid positive rate for SARS-CoV-2 in the outpatients from our fever clinic was 67·1%, while the majority of patients with COVID-19 were mild cases. The predominant initial symptom in those patients with COVID-19 was fever (78.2%), followed by cough (15.6%). Very significantly lower number of eosinophils was characterized in patients with COVID-19 as compared with that of nucleic acid negative patients. More importantly, the proportion of subjects with eosinophil counts lower than normal levels in patients with COVID-19 was much higher than that of nucleic acid negative patients. Fever combined with bilateral ground-glass opacities in computed tomography imaging and eosinophil count below the normal level are probably a valuable indicator of COVID-19 infection in those outpatients.

CONCLUSIONS:

Those findings may provide critical information for the regions, such as Europe and United States that are facing the same situation as Wuhan experienced, and could be valuable to prevent those nucleic acid negative patients from misdiagnosis before antibody testing.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / Fever / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26175

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / Fever / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26175