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Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019.
Zhang, Yonghong; Qin, Ling; Zhao, Yan; Zhang, Ping; Xu, Bin; Li, Kang; Liang, Lianchun; Zhang, Chi; Dai, Yanchao; Feng, Yingmei; Sun, Jianping; Hu, Zhongjie; Xiang, Haiping; Knight, Julian C; Dong, Tao; Jin, Ronghua.
  • Zhang Y; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Qin L; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, United Kingdom.
  • Zhao Y; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Zhang P; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Xu B; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, United Kingdom.
  • Li K; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Liang L; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Zhang C; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Dai Y; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Feng Y; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Sun J; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Hu Z; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Xiang H; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Knight JC; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Dong T; Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
  • Jin R; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, United Kingdom.
J Infect Dis ; 222(1): 34-37, 2020 06 16.
Article in English | MEDLINE | ID: covidwho-599711
ABSTRACT
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / RNA-Binding Proteins / Coronavirus Infections / Polymorphism, Single Nucleotide / Alleles / Betacoronavirus / Membrane Proteins Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / RNA-Binding Proteins / Coronavirus Infections / Polymorphism, Single Nucleotide / Alleles / Betacoronavirus / Membrane Proteins Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2020 Document Type: Article