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Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers.
Pan, Yanfeng; Yu, Xue; Du, Xinwei; Li, Qingqing; Li, Xianyang; Qin, Tao; Wang, Miaomiao; Jiang, Minlin; Li, Jie; Li, Weiguo; Zhang, Qian; Xu, Zhiwei; Zhang, Lu.
  • Pan Y; Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
  • Yu X; Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
  • Du X; Department of Infectious Diseases, The People's Hospital of Suzhou New District, Suzhou, Jiangsu, China.
  • Li Q; Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
  • Li X; Department of Infectious Diseases, Shenqiu County People's Hospital, Zhoukou City, Henan Province, China.
  • Qin T; Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
  • Wang M; Department of Disease Control and Prevention, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
  • Jiang M; Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Shanghai, China.
  • Li J; Department of Infectious Diseases, Xiayi County People's Hospital, Shangqiu City, Henan Province, China.
  • Li W; Department of Infectious Diseases, Zhumadian Central Hospital, Zhumadian, Henan Province, China.
  • Zhang Q; Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
  • Xu Z; Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.
  • Zhang L; Department of Infectious Diseases, Yongcheng People's Hospital, Shangqiu City, Henan Province, China.
J Infect Dis ; 221(12): 1940-1947, 2020 06 11.
Article in English | MEDLINE | ID: covidwho-599713
ABSTRACT

BACKGROUND:

We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers.

METHODS:

Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained.

RESULTS:

Twenty-two patients (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8-24 days) and 21.5 days (10-36 days), respectively. The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n = 16, 61.5%; 7.5 days [2-20 days]) and patients with typical ground-glass or patchy opacities on CT (n = 10, 38.5%; 12.5 days [8-22 days]; P < .01). Seven patients (70.0%) with initial positive nucleic acid test results had a negative result simultaneously with improved CT findings. Obvious improvement in CT findings was observed in 3 patients (30.0%) despite positive nucleic acid test results.

CONCLUSIONS:

In asymptomatic patients, changes in biochemical and inflammatory variables are small and changes on chest CT can occur. It is worth noting that the long existence of SARS-CoV-2 in some asymptomatic patients and false-negative results need to be considered in SARS-CoV-2 nucleic acid test.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Carrier State / Coronavirus Infections / Asymptomatic Infections Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Carrier State / Coronavirus Infections / Asymptomatic Infections Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis