Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
Cytometry A
; 97(8): 772-776, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-600033
ABSTRACT
A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID-19) patients. In this brief meta-analysis, the reduction of lymphocyte subset counts in COVID-19 patients was investigated across 20 peer-reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID-19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID-19 disease compared to mild/moderate disease. T-cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T-cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
B-Lymphocytes
/
Killer Cells, Natural
/
CD4-Positive T-Lymphocytes
/
T-Lymphocyte Subsets
/
Coronavirus Infections
/
CD8-Positive T-Lymphocytes
Type of study:
Observational study
/
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Cytometry A
Year:
2020
Document Type:
Article
Affiliation country:
Cyto.a.24172
Similar
MEDLINE
...
LILACS
LIS