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Thromboembolic events and Covid-19.
Ribes, Agnès; Vardon-Bounes, Fanny; Mémier, Vincent; Poette, Michael; Au-Duong, Jonathan; Garcia, Cédric; Minville, Vincent; Sié, Pierre; Bura-Rivière, Alessandra; Voisin, Sophie; Payrastre, Bernard.
  • Ribes A; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
  • Vardon-Bounes F; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Pôle Anesthésie-Réanimation, CHU de Toulouse, 31059, Toulouse, France.
  • Mémier V; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
  • Poette M; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Pôle Anesthésie-Réanimation, CHU de Toulouse, 31059, Toulouse, France.
  • Au-Duong J; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Pôle Anesthésie-Réanimation, CHU de Toulouse, 31059, Toulouse, France.
  • Garcia C; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
  • Minville V; Pôle Anesthésie-Réanimation, CHU de Toulouse, 31059, Toulouse, France.
  • Sié P; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
  • Bura-Rivière A; Service de Médecine Vasculaire, CHU de Toulouse, 31059, Toulouse, France.
  • Voisin S; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France.
  • Payrastre B; Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France. Electronic address: bernard.payrastre@inserm.fr.
Adv Biol Regul ; 77: 100735, 2020 08.
Article in English | MEDLINE | ID: covidwho-600913
ABSTRACT
The novel Corona virus infection (Covid-19) first identified in China in December 2019 has rapidly progressed in pandemic leading to significant mortality and unprecedented challenge for healthcare systems. Although the clinical spectrum of Covid-19 is variable, acute respiratory failure and systemic coagulopathy are common in severe Covid-19 patients. Lung is an important target of the SARS-CoV-2 virus causing eventually acute respiratory distress syndrome associated to a thromboinflammatory state. The cytokinic storm, thromboinflammation and pulmonary tropism are the bedrock of tissue lesions responsible for acute respiratory failure and for prolonged infection that may lead to multiple organ failure and death. The thrombogenicity of this infectious disease is illustrated by the high frequency of thromboembolic events observed even in Covid-19 patients treated with anticoagulation. Increased D-Dimers, a biomarker reflecting activation of hemostasis and fibrinolysis, and low platelet count (thrombocytopenia) are associated with higher mortality in Covid-19 patients. In this review, we will summarize our current knowledge on the thromboembolic manifestations, the disturbed hemostatic parameters, and the thromboinflammatory conditions associated to Covid-19 and we will discuss the modalities of anticoagulant treatment or other potential antithrombotic options.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Embolism / Respiratory Insufficiency / Coronavirus Infections / Disseminated Intravascular Coagulation / Betacoronavirus / Cytokine Release Syndrome / Anticoagulants Type of study: Diagnostic study / Prognostic study Topics: Long Covid Language: English Journal: Adv Biol Regul Year: 2020 Document Type: Article Affiliation country: J.jbior.2020.100735

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Embolism / Respiratory Insufficiency / Coronavirus Infections / Disseminated Intravascular Coagulation / Betacoronavirus / Cytokine Release Syndrome / Anticoagulants Type of study: Diagnostic study / Prognostic study Topics: Long Covid Language: English Journal: Adv Biol Regul Year: 2020 Document Type: Article Affiliation country: J.jbior.2020.100735