Stopping lopinavir/ritonavir in COVID-19 patients: duration of the drug interacting effect.

Stader, Felix; Khoo, Saye; Stoeckle, Marcel; Back, David; Hirsch, Hans H; Battegay, Manuel; Marzolini, Catia

Stader, Felix; Khoo, Saye; Stoeckle, Marcel; Back, David; Hirsch, Hans H; Battegay, Manuel; Marzolini, Catia.

Stader F; Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Khoo S; University of Basel, Basel, Switzerland.
Stoeckle M; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Back D; Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Hirsch HH; University of Basel, Basel, Switzerland.
Battegay M; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Marzolini C; Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.

J Antimicrob Chemother ; 75(10): 3084-3086, 2020 10 01.

Article in English | MEDLINE | ID: covidwho-600955

Subject(s)

Betacoronavirus; Coronavirus Infections/metabolism; Cytochrome P-450 CYP3A Inhibitors/metabolism; Drug Interactions/physiology; Lopinavir/metabolism; Pneumonia, Viral/metabolism; Ritonavir/metabolism; Adult; Aged; Aged, 80 and over; COVID-19; Coronavirus Infections/drug therapy; Cytochrome P-450 CYP3A Inhibitors/administration & dosage; Drug Therapy, Combination; Female; Humans; Lopinavir/administration & dosage; Male; Middle Aged; Pandemics; Pneumonia, Viral/drug therapy; Ritonavir/administration & dosage; SARS-CoV-2; Time Factors; Withholding Treatment/trends; Young Adult

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Ritonavir / Drug Interactions / Lopinavir / Cytochrome P-450 CYP3A Inhibitors / Betacoronavirus Type of study: Experimental Studies Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Antimicrob Chemother Year: 2020 Document Type: Article Affiliation country: Jac

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