The protective potential of Fc-mediated antibody functions against influenza virus and other viral pathogens.
Immunol Cell Biol
; 98(4): 253-263, 2020 04.
Article
in English
| MEDLINE | ID: covidwho-601138
ABSTRACT
In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc-mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza-specific antibodies with Fc-mediated functions, such as antibody-dependent cellular cytotoxicity and antibody-dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc-mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc-mediated effector functions against viral infections with a focus on influenza virus.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Orthomyxoviridae
/
Phagocytosis
/
Immunoglobulin Fc Fragments
/
Receptors, Fc
/
Influenza, Human
/
Antibodies, Neutralizing
/
Antibodies, Viral
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Immunol Cell Biol
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
Affiliation country:
Imcb.12312
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