Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies.
J Alzheimers Dis
; 76(1): 21-25, 2020.
Article
in English
| MEDLINE | ID: covidwho-601164
ABSTRACT
There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune response and excessive inflammation in COVID-19 may also accelerate the progression of brain inflammatory neurodegeneration, and elderly individuals are more susceptible to severe outcomes after SARS-CoV-2 infection. Individuals with type 2 diabetes (T2D) are at an increased risk for AD as well as severe outcomes after SARS-CoV-2 infection. Genetic and socioeconomic factors influencing the rates of T2D, AD, and COVID-19 severity may create an exceptionally high-risk profile for certain demographics such as African Americans and Hispanic Americans. Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Interferon Type I
/
Coronavirus Infections
/
Diabetes Mellitus, Type 2
/
Pandemics
/
Alzheimer Disease
Type of study:
Prognostic study
Limits:
Aged
/
Humans
Language:
English
Journal:
J Alzheimers Dis
Journal subject:
Geriatrics
/
Neurology
Year:
2020
Document Type:
Article
Affiliation country:
JAD-200537
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