Your browser doesn't support javascript.
Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series.
Tabatabai, Ali; Rabin, Joseph; Menaker, Jay; Madathil, Ronson; Galvagno, Samuel; Menne, Ashley; Chow, Jonathan H; Grazioli, Alison; Herr, Daniel; Tanaka, Kenichi; Scalea, Thomas; Mazzeffi, Michael.
  • Tabatabai A; From the Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Medicine.
  • Rabin J; Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Surgery.
  • Menaker J; Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Surgery.
  • Madathil R; Division of Cardiothoracic Surgery, Department of Surgery.
  • Galvagno S; Department of Anesthesiology.
  • Menne A; Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
  • Chow JH; Department of Anesthesiology.
  • Grazioli A; Department of Nephrology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
  • Herr D; From the Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Medicine.
  • Tanaka K; Department of Anesthesiology.
  • Scalea T; Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Surgery.
  • Mazzeffi M; Department of Anesthesiology.
A A Pract ; 14(7): e01236, 2020 May.
Article in English | MEDLINE | ID: covidwho-601387
ABSTRACT
Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Factor VIII / Protein C / Coronavirus Infections / Thrombophilia Type of study: Observational study Language: English Journal: A A Pract Year: 2020 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Factor VIII / Protein C / Coronavirus Infections / Thrombophilia Type of study: Observational study Language: English Journal: A A Pract Year: 2020 Document Type: Article