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Case report: use of lenzilumab and tocilizumab for the treatment of coronavirus disease 2019.
Melody, Megan; Nelson, Jared; Hastings, Jacquelyn; Propst, Joshua; Smerina, Michael; Mendez, Julio; Guru, Pramod.
  • Melody M; Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Nelson J; Division of Infectious Disease, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Hastings J; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Propst J; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Smerina M; Department of Internal Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Mendez J; Division of Infectious Disease, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Guru P; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL 32224, USA.
Immunotherapy ; 12(15): 1121-1126, 2020 10.
Article in English | MEDLINE | ID: covidwho-602002
ABSTRACT

Background:

Coronavirus disease 2019 (COVID-19) is a novel disease associated with a cytokine-mediated, severe, acute respiratory syndrome. Tocilizumab and lenzilumab are recombinant monoclonal antibodies against IL-6 and granulocyte macrophage colony-stimulating factor, respectively, and have been proposed as a potential treatment for acute, hypoxic respiratory failure associated with COVID-19. Results & 

methodology:

We present the case of a 68-year-old man with COVID-19 who was initially treated with hydroxychloroquine and lenzilumab, but continued to develop hypoxemia, requiring an increase in respiratory support with an associated rise in serum inflammatory markers. He was subsequently treated with tocilizumab with marked clinical improvement and a decrease in acute phase reactants within 48 h. Discussion & 

conclusion:

This case demonstrates the effective use of tocilizumab in the treatment of COVID-19 and suggests the superiority of tocilizumab over lenzilumab in the management of this cytokine-mediated syndrome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Monoclonal, Humanized Type of study: Case report / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Immunotherapy Journal subject: Allergy and Immunology / Therapeutics Year: 2020 Document Type: Article Affiliation country: Imt-2020-0136

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibodies, Monoclonal, Humanized Type of study: Case report / Prognostic study Limits: Aged / Humans / Male Language: English Journal: Immunotherapy Journal subject: Allergy and Immunology / Therapeutics Year: 2020 Document Type: Article Affiliation country: Imt-2020-0136