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Apelin-potential therapy for COVID-19?
Saeedi Saravi, Seyed Soheil; Beer, Jürg H.
  • Saeedi Saravi SS; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland.
  • Beer JH; Center for Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Baden, Switzerland. Electronic address: hansjuerg.beer@ksb.ch.
J Mol Cell Cardiol ; 145: 84-87, 2020 08.
Article in English | MEDLINE | ID: covidwho-602090
ABSTRACT
We believe that, in parallel to the attempts for direct blockade of the SARS-CoV-2 penetration into host cell and repurposing drugs, finding new therapeutic strategies for patients with lung injury or cardiovascular complications/coagulopathies associated with COVID-19 should be paid particular attention. Apelin or its receptor agonists are of great potential treatment for COVID-19 through suppressing angiotensin-converting enzyme (ACE) and angiotensin II (Ang-II) production, as well as, down-regulating angiotensin receptor 1 (AT1R) and ACE2 up-regulation. These drugs have potential to improve acute lung injury and cardiovascular/coagulopathy complications in COVID-19 which are associated with elevated Ang-II/Ang(1-7) ratio.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Angiotensin-Converting Enzyme Inhibitors / Coronavirus Infections / Peptidyl-Dipeptidase A / Angiotensin II Type 1 Receptor Blockers / Betacoronavirus / Apelin / Apelin Receptors Limits: Animals / Humans Language: English Journal: J Mol Cell Cardiol Year: 2020 Document Type: Article Affiliation country: J.yjmcc.2020.06.007

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Angiotensin-Converting Enzyme Inhibitors / Coronavirus Infections / Peptidyl-Dipeptidase A / Angiotensin II Type 1 Receptor Blockers / Betacoronavirus / Apelin / Apelin Receptors Limits: Animals / Humans Language: English Journal: J Mol Cell Cardiol Year: 2020 Document Type: Article Affiliation country: J.yjmcc.2020.06.007