Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents.
Sci Adv
; 6(23): eaaz5466, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-602279
ABSTRACT
Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently, studies on confirmed COVID-19 cases have suggested that mortality might be due to virally induced hyperinflammation. Uncontrolled pro-inflammatory states are often driven by continuous positive feedback loops between pro-inflammatory signaling and oxidative stress, which cannot be resolved in a targeted manner. Here, we report on the development of multidrug nanoparticles for the mitigation of uncontrolled inflammation. The nanoparticles are made by conjugating squalene, a natural lipid, to adenosine, an endogenous immunomodulator, and then encapsulating α-tocopherol, as antioxidant. This resulted in high drug loading, biocompatible, multidrug nanoparticles. By exploiting the endothelial dysfunction at sites of acute inflammation, these multidrug nanoparticles delivered the therapeutic agents in a targeted manner, conferring survival advantage to treated animals in models of endotoxemia. Selectively delivering adenosine and antioxidants together could serve as a novel therapeutic approach for safe treatment of acute paradoxal inflammation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Squalene
/
Drug Delivery Systems
/
Systemic Inflammatory Response Syndrome
/
Endotoxemia
/
Nanoparticles
Type of study:
Prognostic study
Language:
English
Journal:
Sci Adv
Year:
2020
Document Type:
Article
Affiliation country:
Sciadv.aaz5466
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