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The impact of COPD and smoking history on the severity of COVID-19: A systemic review and meta-analysis.
Zhao, Qianwen; Meng, Meng; Kumar, Rahul; Wu, Yinlian; Huang, Jiaofeng; Lian, Ningfang; Deng, Yunlei; Lin, Su.
  • Zhao Q; Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
  • Meng M; Digestion Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
  • Kumar R; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.
  • Wu Y; Liver Research Center, The First Affiliated Hospitals of Fujian Medical University, Fujian, China.
  • Huang J; Liver Research Center, The First Affiliated Hospitals of Fujian Medical University, Fujian, China.
  • Lian N; Department of Respiratory, The First Affiliated Hospitals of Fujian Medical University, Fujian, China.
  • Deng Y; Department of Nephrology, The Third People's Hospital of Chengdu, Chengdu, China.
  • Lin S; Liver Research Center, The First Affiliated Hospitals of Fujian Medical University, Fujian, China.
J Med Virol ; 92(10): 1915-1921, 2020 10.
Article in English | MEDLINE | ID: covidwho-60280
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Chronic Obstructive Airway Disease PREDISPOSES COVID-19
Subject
Chronic Obstructive Airway Disease
Predicate
PREDISPOSES
Object
COVID-19
3. Smoking History PREDISPOSES COVID-19
Subject
Smoking History
Predicate
PREDISPOSES
Object
COVID-19
4. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 OCCURS_IN Patients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Patients
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Chronic Obstructive Airway Disease PREDISPOSES COVID-19
Subject
Chronic Obstructive Airway Disease
Predicate
PREDISPOSES
Object
COVID-19
8. Smoking History PREDISPOSES COVID-19
Subject
Smoking History
Predicate
PREDISPOSES
Object
COVID-19
9. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
Patients
10. COVID-19 OCCURS_IN Patients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Patients
ABSTRACT
Comorbidities are associated with the severity of coronavirus disease 2019 (COVID-19). This meta-analysis aimed to explore the risk of severe COVID-19 in patients with pre-existing chronic obstructive pulmonary disease (COPD) and ongoing smoking history. A comprehensive systematic literature search was carried out to find studies published from December 2019 to 22 March 2020 from five databases. The languages of literature included English and Chinese. The point prevalence of severe COVID-19 in patients with pre-existing COPD and those with ongoing smoking was evaluated with this meta-analysis. Overall 11 case series, published either in Chinese or English language with a total of 2002 cases, were included in this study. The pooled OR of COPD and the development of severe COVID-19 was 4.38 (fixed-effects model; 95% CI 2.34-8.20), while the OR of ongoing smoking was 1.98 (fixed-effects model; 95% CI 1.29-3.05). There was no publication bias as examined by the funnel plot and Egger's test (P = not significant). The heterogeneity of included studies was moderate for both COPD and ongoing smoking history on the severity of COVID-19. COPD and ongoing smoking history attribute to the worse progression and outcome of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Smoking / Pulmonary Disease, Chronic Obstructive / COVID-19 Subject: Smoking / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Prognostic study / Risk factors / Systematic review Language: English Journal: J Med Virol Clinical aspect: Etiology Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Smoking / Pulmonary Disease, Chronic Obstructive / COVID-19 Subject: Smoking / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Prognostic study / Risk factors / Systematic review Language: English Journal: J Med Virol Clinical aspect: Etiology Year: 2020
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