SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells.

Mu, Jingfang; Xu, Jiuyue; Zhang, Leike; Shu, Ting; Wu, Di; Huang, Muhan; Ren, Yujie; Li, Xufang; Geng, Qing; Xu, Yi; Qiu, Yang; Zhou, Xi

Mu, Jingfang; Xu, Jiuyue; Zhang, Leike; Shu, Ting; Wu, Di; Huang, Muhan; Ren, Yujie; Li, Xufang; Geng, Qing; Xu, Yi; Qiu, Yang; Zhou, Xi.

Mu J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Xu J; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, 430023, China.
Zhang L; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Shu T; The University of Chinese Academy of Sciences, Beijing, 100049, China.
Wu D; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Huang M; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Ren Y; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, 430023, China.
Li X; Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan, 430040, China.
Geng Q; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Xu Y; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, 430023, China.
Qiu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
Zhou X; Joint Laboratory of Infectious Diseases and Health, Wuhan Institute of Virology & Wuhan Jinyintan Hospital, CAS, Wuhan, 430023, China.

Sci China Life Sci ; 63(9): 1413-1416, 2020 09.

Article in English | MEDLINE | ID: covidwho-60366

Subject(s)

Betacoronavirus/genetics; Coronavirus Infections/genetics; Coronavirus Infections/virology; Nucleocapsid Proteins/genetics; Pneumonia, Viral/genetics; Pneumonia, Viral/virology; RNA Interference; Betacoronavirus/pathogenicity; Betacoronavirus/physiology; COVID-19; Coronavirus Nucleocapsid Proteins; DEAD-box RNA Helicases/metabolism; Green Fluorescent Proteins/antagonists & inhibitors; Green Fluorescent Proteins/genetics; HEK293 Cells; Humans; Nucleocapsid Proteins/physiology; Pandemics; Phosphoproteins; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; RNA-Binding Proteins/genetics; RNA-Binding Proteins/physiology; Ribonuclease III/metabolism; SARS-CoV-2; Transfection

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Nucleocapsid Proteins / RNA Interference / Betacoronavirus Limits: Humans Language: English Journal: Sci China Life Sci Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S11427-020-1692-1

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