The parent drugs chloroquine and hydroxychloroquine do not inhibit human CYP3A activity in vitro.

Li, Xia; Höhl, Rainer; Sörgel, Fritz; Fuhr, Uwe

Li, Xia; Höhl, Rainer; Sörgel, Fritz; Fuhr, Uwe.

Li X; Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.
Höhl R; Institute for Clinical Hygiene, Medical Microbiology and Clinical Infectiology, Paracelsus Medical Private University, Nuremberg Hospital, Nuremberg, Germany.
Sörgel F; IMBP-Institute for Biomedical and Pharmaceutical Research, Nürnberg, Heroldsberg, Germany.
Fuhr U; Institute of Pharmacology, West German Heart and Vascular Centre, University of Duisburg-Essen, Essen, Germany.

Eur J Clin Pharmacol ; 76(10): 1481-1482, 2020 Oct.

Article in English | MEDLINE | ID: covidwho-603745

Subject(s)

Chloroquine/pharmacology; Cytochrome P-450 CYP3A/drug effects; Hydroxychloroquine/pharmacology; Antirheumatic Agents/pharmacology; Cytochrome P-450 CYP3A/metabolism; Drug Interactions; Humans; In Vitro Techniques

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / Cytochrome P-450 CYP3A / Hydroxychloroquine Limits: Humans Language: English Journal: Eur J Clin Pharmacol Year: 2020 Document Type: Article Affiliation country: S00228-020-02928-7

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