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SARS CoV-2 aggravates cellular metabolism mediated complications in COVID-19 infection.
Singh, Yogendra; Gupta, Gaurav; Kazmi, Imran; Al-Abbasi, Fahad A; Negi, Poonam; Chellappan, Dinesh Kumar; Dua, Kamal.
  • Singh Y; Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, India.
  • Gupta G; School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.
  • Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Al-Abbasi FA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Negi P; School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.
  • Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
  • Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, New South Wales, Australia.
Dermatol Ther ; 33(6): e13871, 2020 11.
Article in English | MEDLINE | ID: covidwho-603778
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the primary causative organism in corona virus disease-19 (COVID-19) infections, is a novel member of the human coronavirus family which was first identified in Wuhan, China, towards the end of 2019. This letter reveals new vital missing links in our current understanding of the mechanisms that lead to cell death triggered by ferroptotic stress in COVID-19 infection. It further reveal the importance of homocysteine mediated trans-sulfuration pathway in COVID-19 infection. Hence, Vitamin B6, folic acid, and Vitamin B12 should be incorporated in the treatment regimen for SARS CoV-2 infections to suppress complications, as the virus mediates altered host cell metabolism.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Death / Ferroptosis / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Dermatol Ther Journal subject: Dermatology Year: 2020 Document Type: Article Affiliation country: Dth.13871

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Death / Ferroptosis / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Dermatol Ther Journal subject: Dermatology Year: 2020 Document Type: Article Affiliation country: Dth.13871