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Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19.
Dudoignon, Emmanuel; Moreno, Nabila; Deniau, Benjamin; Coutrot, Maxime; Longer, Romain; Amiot, Quentin; Mebazaa, Alexandre; Pirracchio, Romain; Depret, François; Legrand, Matthieu.
  • Dudoignon E; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France.
  • Moreno N; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France.
  • Deniau B; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; Inserm UMR-S 942, Mascot, Lariboisière Hospital, Paris, France.
  • Coutrot M; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France.
  • Longer R; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France.
  • Amiot Q; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France.
  • Mebazaa A; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France.
  • Pirracchio R; Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University of California, San Francisco, California.
  • Depret F; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France.
  • Legrand M; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France; Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University o
Anaesth Crit Care Pain Med ; 39(4): 453-455, 2020 08.
Article in English | MEDLINE | ID: covidwho-603939
ABSTRACT
The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Acute Kidney Injury / Betacoronavirus Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Anaesth Crit Care Pain Med Year: 2020 Document Type: Article Affiliation country: J.accpm.2020.06.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Acute Kidney Injury / Betacoronavirus Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Anaesth Crit Care Pain Med Year: 2020 Document Type: Article Affiliation country: J.accpm.2020.06.006