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Prognostic value of NT-proBNP in patients with severe COVID-19.
Gao, Lei; Jiang, Dan; Wen, Xue-Song; Cheng, Xiao-Cheng; Sun, Min; He, Bin; You, Lin-Na; Lei, Peng; Tan, Xiao-Wei; Qin, Shu; Cai, Guo-Qiang; Zhang, Dong-Ying.
  • Gao L; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Jiang D; Department of Cardiovascular Medicine, The First Branch of the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Wen XS; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Cheng XC; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Sun M; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • He B; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • You LN; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Lei P; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Tan XW; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Qin S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Cai GQ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 185161439@qq.com.
  • Zhang DY; Traditional Chinese Medicine hospital Dianjiang Chongqing, Chongqing, 408300, China. 185161439@qq.com.
Respir Res ; 21(1): 83, 2020 Apr 15.
Article in English | MEDLINE | ID: covidwho-60448
ABSTRACT

BACKGROUND:

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.

METHODS:

The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.

RESULTS:

The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.

CONCLUSION:

NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19. TRIAL REGISTRATION ClinicalTrials, NCT04292964. Registered 03 March 2020.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Pneumonia, Viral / Hospital Mortality / Coronavirus Infections / Natriuretic Peptide, Brain / Pandemics Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Respir Res Year: 2020 Document Type: Article Affiliation country: S12931-020-01352-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Pneumonia, Viral / Hospital Mortality / Coronavirus Infections / Natriuretic Peptide, Brain / Pandemics Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Respir Res Year: 2020 Document Type: Article Affiliation country: S12931-020-01352-w