Immune checkpoint inhibitors: a physiology-driven approach to the treatment of coronavirus disease 2019.
Eur J Cancer
; 135: 62-65, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-605486
ABSTRACT
While confirmed cases of the deadly coronavirus disease 2019 (COVID-19) have exceeded 4.7 million globally, scientists are pushing forward with efforts to develop vaccines and treatments in an attempt to slow the pandemic and lessen the disease's damage. Although no proven effective therapies for treating patients with COVID-19 or for managing their complications currently exist, the rapidly expanding knowledge regarding severe acute respiratory syndrome coronavirus 2 and its interplay with hosts provides a significant number of potential drug targets and the potential to repurpose drugs already tested in other diseases. Herein, we report the biological rationale of immune-activating drugs and a brief summary of literature data on the potential therapeutic value of immune checkpoint inhibitors that have been recently tested beyond cancer treatment for their potential to restore cellular immunocompetence.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Betacoronavirus
/
Immunologic Factors
/
Neoplasms
Type of study:
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Language:
English
Journal:
Eur J Cancer
Year:
2020
Document Type:
Article
Affiliation country:
J.ejca.2020.05.026
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