Cytokine Storm in COVID19: A Neural Hypothesis.

Ur, Anoop; Verma, Kavita

Ur, Anoop; Verma, Kavita.

Ur A; UR Anoop Research Group, Pondicherry 605008, India.
Verma K; UR Anoop Research Group, Pondicherry 605008, India.

ACS Chem Neurosci ; 11(13): 1868-1870, 2020 07 01.

Article in English | MEDLINE | ID: covidwho-606648

ABSTRACT

ABSTRACT

Cytokine storm in COVID-19 is characterized by an excessive inflammatory response to SARS-CoV-2 that is caused by a dysregulated immune system of the host. We are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of nucleus tractus solitarius (NTS) may be responsible for the cytokine storm in COVID 19. The inflamed NTS may result in a dysregulated cholinergic anti-inflammatory pathway and hypothalamic-pituitary-adrenal axis.

Subject(s)

Betacoronavirus/metabolism; Coronavirus Infections/metabolism; Cytokines/metabolism; Pneumonia, Viral/metabolism; Solitary Nucleus/metabolism; Axons/immunology; Axons/metabolism; Axons/virology; Betacoronavirus/immunology; COVID-19; Coronavirus Infections/immunology; Cranial Nerves/immunology; Cranial Nerves/metabolism; Cranial Nerves/virology; Cytokines/immunology; Humans; Hypothalamo-Hypophyseal System/immunology; Hypothalamo-Hypophyseal System/metabolism; Hypothalamo-Hypophyseal System/virology; Inflammation Mediators/immunology; Inflammation Mediators/metabolism; Pandemics; Pituitary-Adrenal System/immunology; Pituitary-Adrenal System/metabolism; Pituitary-Adrenal System/virology; Pneumonia, Viral/immunology; SARS-CoV-2; Solitary Nucleus/immunology; Solitary Nucleus/virology

Keywords

COVID-19; cholinergic anti-inflammatory pathway; cytokine storm; cytokines; hypothalamic−pituitary−adrenal axis; nucleus tractus solitarius

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Solitary Nucleus / Coronavirus Infections / Betacoronavirus Limits: Humans Language: English Journal: ACS Chem Neurosci Year: 2020 Document Type: Article Affiliation country: Acschemneuro.0c00346

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google