Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.
Molecules
; 25(12)2020 Jun 16.
Article
in English
| MEDLINE | ID: covidwho-606990
ABSTRACT
BACKGROUND:
In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry.OBJECTIVES:
Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.METHODS:
Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020.RESULTS:
A final total of 20 studies included in this review.CONCLUSIONS:
This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Quinoxalines
/
Coronavirus Infections
/
Betacoronavirus
Type of study:
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal subject:
Biology
Year:
2020
Document Type:
Article
Affiliation country:
Molecules25122784
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