Your browser doesn't support javascript.
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Thomas, Tiffany; Stefanoni, Davide; Reisz, Julie A; Nemkov, Travis; Bertolone, Lorenzo; Francis, Richard O; Hudson, Krystalyn E; Zimring, James C; Hansen, Kirk C; Hod, Eldad A; Spitalnik, Steven L; D'Alessandro, Angelo.
  • Thomas T; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • Stefanoni D; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Bertolone L; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Francis RO; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • Hudson KE; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • Zimring JC; Department of Pathology, University of Virginia, Charlottesville, Virginia, USA.
  • Hansen KC; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
  • Hod EA; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • Spitalnik SL; Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado, USA.
JCI Insight ; 5(14)2020 07 23.
Article in English | MEDLINE | ID: covidwho-607189
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
3. Kynurenine AFFECTS Inflammation
Subject
Kynurenine
Predicate
AFFECTS
Object
Inflammation
4. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
5. nitrogen PART_OF Patients
Subject
nitrogen
Predicate
PART_OF
Object
Patients
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
8. Kynurenine AFFECTS Inflammation
Subject
Kynurenine
Predicate
AFFECTS
Object
Inflammation
9. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
10. nitrogen PART_OF Patients
Subject
nitrogen
Predicate
PART_OF
Object
Patients
ABSTRACT
BACKGROUNDReprogramming of host metabolism supports viral pathogenesis by fueling viral proliferation, by providing, for example, free amino acids and fatty acids as building blocks.METHODSTo investigate metabolic effects of SARS-CoV-2 infection, we evaluated serum metabolites of patients with COVID-19 (n = 33; diagnosed by nucleic acid testing), as compared with COVID-19-negative controls (n = 16).RESULTSTargeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity. Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels. Widespread dysregulation of nitrogen metabolism was also seen in infected patients, with altered levels of most amino acids, along with increased markers of oxidant stress (e.g., methionine sulfoxide, cystine), proteolysis, and renal dysfunction (e.g., creatine, creatinine, polyamines). Increased circulating levels of glucose and free fatty acids were also observed, consistent with altered carbon homeostasis. Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections / Oxidative Stress / Renal Insufficiency / Fatty Acids / Kynurenine Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Jci.insight.140327

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections / Oxidative Stress / Renal Insufficiency / Fatty Acids / Kynurenine Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Jci.insight.140327