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Infant With SARS-CoV-2 Infection Causing Severe Lung Disease Treated With Remdesivir.
Frauenfelder, Claire; Brierley, Joe; Whittaker, Elizabeth; Perucca, Giulia; Bamford, Alasdair.
  • Frauenfelder C; Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, United Kingdom.
  • Brierley J; Division of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia.
  • Whittaker E; Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, United Kingdom.
  • Perucca G; Department of Paediatric Infectious Diseases, Imperial College Healthcare National Health Service Trust, London, United Kingdom; and.
  • Bamford A; Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, United Kingdom.
Pediatrics ; 146(3)2020 09.
Article in English | MEDLINE | ID: covidwho-607311
ABSTRACT
We describe an ex-premature infant presenting with severe acute respiratory syndrome coronavirus 2 infection in the fifth week of life. In current reports, researchers indicate that acute symptomatic severe acute respiratory syndrome coronavirus 2 infection is relatively rare and much less severe than in adults. This case highlights that infection can be associated with life-threatening pulmonary disease in young infants and that infection can follow a similar disease course to that described in adults. We provide first data on the use of the novel antiviral remdesivir in a young child and an innovative approach to expedited approval from a multidisciplinary clinical team and bioethics committee for compassionate access to the drug.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Infant, Premature / Adenosine Monophosphate / Coronavirus Infections / Severe Acute Respiratory Syndrome / Alanine Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Infant Language: English Year: 2020 Document Type: Article Affiliation country: Peds.2020-1701

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Infant, Premature / Adenosine Monophosphate / Coronavirus Infections / Severe Acute Respiratory Syndrome / Alanine Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Infant Language: English Year: 2020 Document Type: Article Affiliation country: Peds.2020-1701